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Compounds and Methods for Modulating Activity of Calcium Release Channels

Using a new assay for drug development (see Abrj-01), PSU researchers have developed new compounds that may prove useful in the treatment of heart arrhythmia. Ventricular arrhythmias appear to be caused by a calcium leak from the sarcoplasmic reticulum in cardiac muscle, and arrhythmias often lead to heart failure. Drugs that prevent and treat arrhythmias...

Published: 7/23/2009 | Updated: 7/23/2009 | Inventor(s): Jonathan Abramson, Robert Strongin

Keywords(s): Chemistry, Therapeutics

Category(s): Therapeutics

Fluorophore-Tagged Cisplatin

Many types of cancer, including carcinomas, lymphomas, sarcomas, and others, are treated with the chemotherapy agent Cisplatin. Based on the element platinum, cisplatin causes apoptosis in cancer cells by cross-linking their DNA. Like many chemotherapy agents, Cisplatin's effectiveness could be improved by better understanding how the body moves it...

Published: 7/24/2009 | Updated: 7/20/2009 | Inventor(s): Robert Strongin, Martha SibriaN-Vazquez, Jorge Escobedo, Peter Streyger

Keywords(s): Biology, Chemistry, Drug Screening, Therapeutics

Category(s): Therapeutics

Solution-Based Synthesis of Functional Graphene

PSU researchers have developed techniques to covalently attach single and multiple layers of graphene sheets on substrates. The graphene can subsequently be functionalized for use in nanobiosensor applications. Procedures are being developed for the solution-based synthesis and functionalization of graphene sheets from graphite in a way that is straightforward,...

Published: 7/29/2009 | Updated: 7/20/2009 | Inventor(s): Mingdi Yan, Li Liu

Keywords(s): Chemistry, Nanotechnology

Category(s): Chemistry

Quinoline Derivatives and Uses Thereof

David Peyton has developed hybrid drugs to overcome drug resistances in Malaria, Cancer, and Tuberculosis.

Published: 7/20/2009 | Updated: 7/20/2009 | Inventor(s): David Peyton

Keywords(s): Chemistry, Therapeutics

Category(s): Chemistry

Immobilizing Polymers on Materials

Ultrathin polymer films are of great interest and utility for their tremendous technological importance in adhesion, chemical sensors, molecular electronics, optical surfaces, and tissue engineering. Many efforts have been focused on the fabrication of uniform, ultrathin polymer films of solid substrates using non-covalent methods such as spin coating,...

Published: 7/30/2009 | Updated: 7/20/2009 | Inventor(s): Mingdi Yan

Keywords(s): Chemistry, Nanotechnology

Category(s): Nanoscience & Microtechnologies

Screen for Redox Activity of Compounds

The design of new and effective drugs is a multi-billion dollar business, requiring great expense and extensive testing of drug candidate compounds. Obtaining a better understanding of the pharmacodynamics and mechanisms of action of drug candidates is an important and necessary step in optimizing any lead compound. A property of increasing...

Published: 7/24/2009 | Updated: 6/3/2009 | Inventor(s): Jonathan Abramson, Benjamin Marinov, Rotimi Olojo

Keywords(s): Biology, Chemistry, Drug Screening

Category(s): Therapeutics

Cleaner, Less Expensive Amine Production

PSU researchers and their collaborators have uncovered and engineered a new class of enzymes - the nitrile oxido reductases - that can aid in the chemical production of amines. In today's society, chemical manufacturing industries are facing increasing demands to practice environmentally conscientious methods and processes. Like all businesses, they...

Published: 7/24/2009 | Updated: 5/26/2009 | Inventor(s): Dirk IwatA-Reuyl, Valerie De CrecY-Lagard, Steven Van Lanen

Keywords(s): Chemistry

Category(s): Chemistry